Libby Lab University of Toronto

Papers

Our list of publications is always growing so to make it easier we have made a list of highlights below

An i in vivo i CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast
An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast
Ashley R. G Libby, Tiago Rito, Arthur Radley, James Briscoe
Development  ·  01 Feb 2025  ·  doi:10.1242/dev.204591
Timely TGFβ signalling inhibition induces notochord
Timely TGFβ signalling inhibition induces notochord
Tiago Rito, Ashley R. G. Libby, Madeleine Demuth, Marie-Charlotte Domart, Jake Cornwall-Scoones, James Briscoe
Nature  ·  18 Dec 2024  ·  doi:10.1038/s41586-024-08332-w
Axial elongation of caudalized human organoids mimics aspects of neural tube development
Axial elongation of caudalized human organoids mimics aspects of neural tube development
Ashley R. G. Libby, David A. Joy, Nicholas H. Elder, Emily A. Bulger, Martina Z. Krakora, Eliza A. Gaylord, Frederico Mendoza-Camacho, Jessica C. Butts, Todd C. McDevitt
Development  ·  15 Jun 2021  ·  doi:10.1242/dev.198275
Automated Design of Pluripotent Stem Cell Self-Organization
Automated Design of Pluripotent Stem Cell Self-Organization
Ashley R.G. Libby, Demarcus Briers, Iman Haghighi, David A. Joy, Bruce R. Conklin, Calin Belta, Todd C. McDevitt
Cell Systems  ·  01 Nov 2019  ·  doi:10.1016/j.cels.2019.10.008

All Papers - with preprints!

Explore all our published research and scientific contributions in developmental biology, stem cell research, and tissue engineering.

2025

An i in vivo i CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast
An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast
Ashley R. G Libby, Tiago Rito, Arthur Radley, James Briscoe
Development  ·  01 Feb 2025  ·  doi:10.1242/dev.204591

2024

Timely TGFβ signalling inhibition induces notochord
Timely TGFβ signalling inhibition induces notochord
Tiago Rito, Ashley R. G. Libby, Madeleine Demuth, Marie-Charlotte Domart, Jake Cornwall-Scoones, James Briscoe
Nature  ·  18 Dec 2024  ·  doi:10.1038/s41586-024-08332-w
An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast
An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast
Ashley RG Libby, Tiago Rito, Arthur Radley, James Briscoe
Cold Spring Harbor Laboratory  ·  16 May 2024  ·  doi:10.1101/2024.05.16.594506
TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids
TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids
Emily A. Bulger, Ivana Muncie-Vasic, Ashley R. G. Libby, Todd C. McDevitt, Benoit G. Bruneau
Development  ·  15 Mar 2024  ·  doi:10.1242/dev.202516
In preprints: puzzling together roles for glucose metabolism during gastrulation
In preprints: puzzling together roles for glucose metabolism during gastrulation
Ashley Libby, Teresa Rayon
Development  ·  15 Feb 2024  ·  doi:10.1242/dev.202774

2023

TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids
TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids
Emily A. Bulger, Ivana Muncie-Vasic, Ashley R.G. Libby, Todd C. McDevitt, Benoit G. Bruneau
Cold Spring Harbor Laboratory  ·  07 Nov 2023  ·  doi:10.1101/2023.11.06.565933
Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells
Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells
Ivana Vasic, Ashley R.G. Libby, Annie Maslan, Emily A. Bulger, David Zalazar, Martina Z. Krakora Compagno, Aaron Streets, Kiichiro Tomoda, Shinya Yamanaka, Todd C. McDevitt
Developmental Cell  ·  01 Aug 2023  ·  doi:10.1016/j.devcel.2023.05.019
Notochord and axial progenitor generation by timely BMP and NODAL inhibition during vertebrate trunk formation
Notochord and axial progenitor generation by timely BMP and NODAL inhibition during vertebrate trunk formation
Tiago Rito, Ashley R.G. Libby, Madeleine Demuth, James Briscoe
Cold Spring Harbor Laboratory  ·  28 Feb 2023  ·  doi:10.1101/2023.02.27.530267

2021

Axial elongation of caudalized human organoids mimics aspects of neural tube development
Axial elongation of caudalized human organoids mimics aspects of neural tube development
Ashley R. G. Libby, David A. Joy, Nicholas H. Elder, Emily A. Bulger, Martina Z. Krakora, Eliza A. Gaylord, Frederico Mendoza-Camacho, Jessica C. Butts, Todd C. McDevitt
Development  ·  15 Jun 2021  ·  doi:10.1242/dev.198275
Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis
Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis
David A. Joy, Ashley R.G. Libby, Todd C. McDevitt
Stem Cell Reports  ·  01 May 2021  ·  doi:10.1016/j.stemcr.2021.04.008

2020

Silencing of E-cadherin in induced human pluripotent stem cells promotes extraembryonic fates accompanying multilineage differentiation
Silencing of E-cadherin in induced human pluripotent stem cells promotes extraembryonic fates accompanying multilineage differentiation
Ashley RG Libby, Ivana Vasic, David A Joy, Martina Z Krakora, Fredrico N Mendoza-Camacho, Bruce R Conklin, Todd C McDevitt
Cold Spring Harbor Laboratory  ·  03 Nov 2020  ·  doi:10.1101/2020.11.01.363713
Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis
Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis
David A. Joy, Ashley R. G. Libby, Todd C. McDevitt
Cold Spring Harbor Laboratory  ·  22 Sep 2020  ·  doi:10.1101/2020.09.21.307470

2019

Automated Design of Pluripotent Stem Cell Self-Organization
Automated Design of Pluripotent Stem Cell Self-Organization
Ashley R.G. Libby, Demarcus Briers, Iman Haghighi, David A. Joy, Bruce R. Conklin, Calin Belta, Todd C. McDevitt
Cell Systems  ·  01 Nov 2019  ·  doi:10.1016/j.cels.2019.10.008

2018

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference
Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference
Ashley RG Libby, David A Joy, Po-Lin So, Mohammad A Mandegar, Jonathon M Muncie, Federico N Mendoza-Camacho, Valerie M Weaver, Bruce R Conklin, Todd C McDevitt
eLife  ·  09 Oct 2018  ·  doi:10.7554/eLife.36045